Subfertile women with WHO class II anovulation who are ovulatory on CC, but have not conceived in 6 ovulatory cycles.
Conditions
Interventions
To study the effectiveness of the following interventions in patients who have not conceived after 5 to 7 ovulatory cycles with CC treatment
1. Extended CC treatment
2. Extended CC treatment combine
Sponsors
Marleen J Nahuis
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients with five to seven ovulatory cycles after CC treatment and no conception. Ovulation is assessed by a midluteal progesterone (> 16 nmol/l), basal temperature curve, detection of LH surge or history. 2. All patients have normal serum FSH ( 80 pmol/l), prolactin (0,05 – 0,80 IU/l) and thyroid-stimulating hormone (0,4 - 4,0 mU/l). 3. All women have patent Fallopian tubes, proven by hysterosalpingography (HSG), a negative Chlamydia antibody titre (CAT) or diagnostic laparoscopy combined with tubal testing (DLS and TT). 4. The partners have normal semen parameters according to the modified criteria of the World Health Organization (1999). 5. Age between 18 and 40 years.
Exclusion criteria
Exclusion criteria: 1. Patients who have previously been treated with gonadotropins or IVF are excluded. 2. Patients are excluded if they have intolerable symptoms when treated with CC like hot flashes affecting daily function, headaches, vision changes, and depression. 3. Patients are excluded if they are remaining anovulatory on CC 150 mg.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome will be pregnancies leading to live birth. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes will be: - clinical pregnancy - miscarriage - multiple pregnancy - occurrence of ovulation - ongoing pregnancy | — |
Contacts
Public ContactMarleen J Nahuis
Medisch Spectrum Twente Locatie Enschede Ariënsplein
Outcome results
None listed