Poor ovarian response
Conditions
Interventions
Group (1) will be pre-treated with oral contraceptive pills (OCP) started on cycle day 2-3 of the preceding cycle for a variable period of 14-21 days. The date of the last OC intake will be decided by
Progestan, Organon
200 mg, three times d
Sponsors
Non
Eligibility
Inclusion criteria
Inclusion criteria: 1. Valid indication for IVF or ICSI; 2. Patients with expected or non expected poor response: A. Expected: i. Aged women > 35 years; ii. And/or women who have a raised basal day 3 FSH level > 10 IU/mL irrespective of age; iii. And/or women who have a low antral follicular count 3000 IU FSH for follicle growth; iii. And/or women who have low oocyte yield < 3-5 follicles despite high daily stimulation dose; iiii. And/or women who have their IVF cycle cancelled due to a low estradiol level < 300-850 pg/ml. 3. Pre-wash total motile sperm count above 10 million or a post-wash total motile sperm count above 1 million.
Exclusion criteria
Exclusion criteria: 1. Women > 43 years old; 2. Polycystic ovary syndrome or any other anovulation; 3. Endocrino pathological disease like: Cushing syndrome, adrenal hyperplasia, hyperprolactinemia, acromegaly, imminent ovarian failure, premature ovarian failure, hypothalamic amenorrhea, hypothyroid, diabetes mellitus type; 4. If not willing or able to sign the consent form.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ongoing pregnancy (OPR) per women randomised (defined as a viable pregnancy of at least 10 weeks of gestation). | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Clinical pregnancy, defined as any registered embryonic heartbeat at sonography; 2. Biochemical pregnancy ((defined as an increase in serum HCG or a positive pregnancy test); 3. Multiple pregnancy, defined as registered heartbeat of at least two foetuses at 6-8 weeks of gestation; 4. Miscarriage rate; 5. Fertilization rate; 6. Number of oocytes; 7. Number of metaphase II oocytes; 8. Number of embryos; 9. Number of ET; 10. Number of embryos frozen; 11. Total FSH dose used for ovarian stimulation; 12. Cancellation rate; 13. Drop-out rate; 14. Costs. | — |
Contacts
Public ContactMohamed A.F. Youssef
Post Office Box 109
Outcome results
None listed