catheter, UTI, urinary tract infection, antibiotic stewardship, catheter-related, urineweginfectie, catheter-gerelateerd
Conditions
Interventions
Patients will be treated with antibiotics according to SWAB/Verenso guideline. In the intervention arm, patients will receive 5 days of therapy. In control arm will receive 10 days of antibiotic treat
Sponsors
Department of Infectious Diseases, Academic Medical Center, Amsterdam
Eligibility
Inclusion criteria
Inclusion criteria: 1. Indwelling (transurethral or supra-pubic) urinary catheter with the intention for long term continuous catheterization, and at least for the next 28 days 2. Signs/symptoms of a systemic UTI, following the modified Loeb criteria [23,24]: a. patient feels sick; b. at least one of the following signs: Fever > 37.9 ºC, Rigors, New onset delirium, New/worsened costovertebral angle tenderness or other local signs of UTI 3. Positive dipstick leucocyte esterase test, or sediment > 10 leucocytes/mm3
Exclusion criteria
Exclusion criteria: 1. Evidence of acute prostatitis or epididymitis 2. Negative urine culture after 3 days, sampled before start of antibiotics. 3. Insufficient understanding of Dutch or English language, or otherwise unable (cognitively impaired or incapacitated) to understand or cooperate in study, or to give informed consent. 4. Patients younger than 18 years of age. 5. Current pregnancy 6. Patients with kidney transplant. 7. Patients with suspected concomitant infection requiring antibiotic treatment 8. Patients with planned removal of catheter or switch to intermittent catheterization within 28 days (4 weeks) after inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary study endpoint is the recurrence of a symptomatic UTI during 90 days after randomization. | — |
Secondary
| Measure | Time frame |
|---|---|
| - recurrence of a symptomatic UTI during 180 days after randomization. - time to recurrence of symptomatic UTI - clinical and microbiological cure at end-of-treatment - results of urine cultures at day 30 and day 90 after randomization - resistance pattern of cultured microorganisms after end-of-treatment - total antibiotic consumption, overall and for UTI during 90 days after randomization - acute hospitalizations for UTI during 90 days after randomization - C. difficile associated diarrhea during 90 days after randomization | — |
Contacts
Public ContactJ.E. Oryszczyn
Academic Medical Center Amsterdam, F4-106
Outcome results
None listed