primary sclerosing cholangitis inflammatory bowel disease ulcerative colitis Crohn's disease primaire scleroserende cholangitis inflammatoire darmziekten colitis ulcerosa ziekte van Crohn
Conditions
Interventions
Ileal and colonic biopsies during colonoscopy.
Sponsors
C.IJ. Ponsioen, MD PhD
Dept. Gastroenterology and Hepatology Academic Medical Center Amsterdam
PO Box 22660
1100 DD Amsterdam
The Netherlands
c.y.ponsioen@amc.uva.nl
Eligibility
Inclusion criteria
Inclusion criteria: 1. Newly diagnosed PSC patients screened for IBD, ≥18 yr old; 2. a. Newly diagnosed UC patients, ≥18 yr old; 2. b. Infectious enterocolitis patients (bacterial/viral/parasitic), ≥18 yr old; 3. PSC/UC surveillance patients, ≥18 yr old; 4. UC surveillance patients, ≥18 yr old; 5. Controls referred for CRC screening, ≥18 yr old.
Exclusion criteria
Exclusion criteria: 1. Inability to give informed consent; 2. Bleeding diathesis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Expression of CCL25 in human colon. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Semiquantitative analyses of CCL25 and/or CCR9+ lymphocytes in double stained colonic biopsies between patients and controls; 2. Quantitative analyses of CCL25 mRNA in colon of patients and controls; 3. Quantitative analyses α4β7/CCR9+ T cells in peripheral blood. | — |
Contacts
Public ContactK. Boonstra
PO Box 22660
Outcome results
None listed