Early detection of breast cancer in women with a familial or genetic predisposition of developing breast cancer using biomarkers in serum

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON26238

Enrollment

1250

Registered

2020-06-22

Start date

2017-05-30

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Breast cancer, hereditary breast cancer

Interventions

Blood draw once every 6 months

Eligibility

Inclusion criteria

Inclusion criteria: - Women - 25-75 years old - Screening indication due to familiar or genetically enhanced risk of developing breast cancer or LTR > 15%

Exclusion criteria

Exclusion criteria: - Previous invasive breast cancer in medical history - Other malignancies within the last 10 years (other than basal cell carcinoma)

Design outcomes

Primary

Measure	Time frame
Analyzing the differences in protein profiles between patients and controls and within patients over time. Moreover, establishing a panel of protein-based biomarkers for the early detection of breast cancer.	—

Secondary

Measure	Time frame
The prognostic value of the selected protein profiles as biomarkers (5-year survival, disease free period and distant mestastasis)	—

Contacts

Public ContactSophie Hagenaars

Leiden University Medical Center

s.c.hagenaars@lumc.nl071-5265130

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)