type 2 diabetes
Conditions
Interventions
Subjects will replace all oral food intake by three identical meals (Enrich Plus, Abbott industries) at fixed timepoints, during three days. Furthermore they will adhere to a fixed sleep wake schedule
Sponsors
P.H.L.T. Bisschop, MD PhD
Department of Endocrinology
Academic Medical Center, Amsterdam
the Netherlands
Eligibility
Inclusion criteria
Inclusion criteria: Patients: 1. Male; 2. Type 2 diabetes; 3. Age 30-75 yr; 4. BMI 25-40 kg/m2. Age matched controls: 1. Age 30-75 yr; 2. Male; 3. BMI <25 kg/m2.
Exclusion criteria
Exclusion criteria: Patients: 1. Use of any other anti-diabetic drug than metformin; 2. Acute or chronic metabolic disease (other than type 2 diabetes) that will impair metabolism or digestion and absorption of food, including gastro-intestinal, hepatic or renal disease; 3. Inability to give informed consent; 4. Shift work in the month before intervention; 5. Crossing several timezones in the month before intervention. Controls: 1. Any acute or chronic metabolic disease that will impair metabolism or digestion and absorption of food, including gastro-intestinal, hepatic or renal disease; 2. Inability to give informed consent; 3. Shift work in the month before intervention; 4. Crossing several timezones in the month before intervention.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Difference between type 2 diabetes patients and healthy controls in circadian rhythm of postprandial glucose excursions, hemostatic parameters and gene expression in adipose tissue. | — |
Secondary
| Measure | Time frame |
|---|---|
| Difference between type 2 diabetes patients and healthy controls in circadian rhythms of insulin excursions, free fatty acid responses and oxidative stress. | — |
Contacts
Public ContactD.J. Stenvers
Room F5-165 Department of Endocrinology and Metabolism Academic Medical Center, Amsterdam
Outcome results
None listed