The effect of Gladskin (Staphefekt) treatment on the severity of skin symptoms in patients with Netherton syndrome

Follow-up treatment with Gladskin in patients with Netherton syndrome

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON26178

Enrollment

Registered

2018-12-12

Start date

2019-01-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

The intervention includes Gladskin (Staphefekt) gel application

Eligibility

Inclusion criteria

Inclusion criteria: - 18 years of age or above - Having a diagnosis of Netherton syndrome - Able to read patient information, fill out online questionnaires and provide informed consent

Exclusion criteria

Exclusion criteria: - Systemic antibiotics within the previous 4 weeks - Topical antibiotics within the previous 7 days - Gladskin within the previous 7 days

Design outcomes

Primary

Measure	Time frame
Patient reported disease severity score using the Patient Global Assessment (PGA)	—

Secondary

Measure	Time frame
- Patient reported disease severity scores (prutitis NRS, pain NRS, desquamation NRS, erythema NRS, sleep NRS) - Visual index for Ichthyosis severity (VIIS) - Staphylococcus aureus load and other microorganisms on skin and nose mucosa measured by DNA based methods and culture - Safety and tolerability of Gladskin	—

Outcome results