low back pain, injection, PRP, discogenic diseases lage rugpijn, injectering, PRP, discogene pijn.
Conditions
Interventions
The intervention to be studied is the intradiscal delivery of Platelet Rich Plasma for proposed symptomatic improvement in pain and function related to treatment of annular tears at the appropriate di
Sponsors
Stichting Rugpoli
Eligibility
Inclusion criteria
Inclusion criteria: The patients are aged between 18 en 65 jaar. Pain persists for an extended period of time (ie >3 months] pain is not responsive to conservative treatment (oral medicatin, rehabilitation). Maintained intervertbral disc heigths of at least 50% and protrusion less than 5mm on MRI. Positive result on the discografie in conformity with Isis Guidelines. The exclusion criteria are not applicable.
Exclusion criteria
Exclusion criteria: Modic Patients unable, according to protocol, to stop taking anticoagulantia. Pregnancy. systemic infection or skin infectin over the puncture site Allergy to contrast Psychiatric conditions Solid bonefusion that does not allow access to the disc Severe intervertebral disc protrusions lager than 5mm, extrusions, or sequestered fragment Severe spinal canal compromise at the disc levels to be investigated Spondylolisthesis level 2 or higher.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome is improvement in pain and function following platelet rich plasma injection. The outcome will be measured by means of Numeric pain scale, Short form health Survey (SF-36), Roland Morris disability questionnaire. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes include observation for any untoward side-effects including increased pain, bleeding, infection and motor or sensory deficits. | — |
Outcome results
None listed