Prematurity, Wheezing, Respiratory Tract Infections
Conditions
Interventions
Sponsors
Franciscus Gasthuis
Eligibility
Inclusion criteria
Inclusion criteria: • Gestational age at delivery between 30+0 and 35+6 weeks • Written informed consent by both parents or formal caregivers
Exclusion criteria
Exclusion criteria: • Underlying other severe respiratory disease such as broncho-pulmonary dysplasia (unexpected in this group) ; diaphragmatic hernia; other serious congenital lung disorders; hemodynamic significant cardiac disease; immunodeficiency; severe failure to thrive; birth asphyxia with predicted poor neurological outcome; syndromic or serious congenital disorders. • Parents unable to speak and read the Dutch or English language
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total number of physician diagnosed lower RTI and wheezing episodes in the first 18 months of life. | — |
Secondary
| Measure | Time frame |
|---|---|
| • time to first lower RTI or wheezing episode • total number of RTI • total number of wheezing episodes • distribution of viruses (in case of hospital admission) • medication use (bronchodilators, corticosteroids, antibiotics) • lung function as measured by expiratory variability index • comparison of expiratory variability index in moderate/late prematurity compared to term cohort • correlation between expiratory variability index and other pulmonary function analyses • association between expiratory variability index and number of RTI/wheezing • outdoor air quality • indoor air quality • association between air quality and number of RTI • quality of life • classification of high risk patients • costs- and cost-effectiveness | — |
Contacts
Public ContactKishan Tsang
Franciscus
Outcome results
None listed