Loss of skeletal muscle mass and strength with aging, also termed sarcopenia
Conditions
Interventions
The experimental trial consists of two 5-d phases separated by 4 weeks of supplementation. Muscle protein synthesis will be determined during the last 2 d of each 5-d phase. For each phase, dietary in
Sponsors
McMaster University
Eligibility
Inclusion criteria
Inclusion criteria: 1) Male 2) Age 65-80 y 3) BMI between 18.5 and 30 kg/m2 4) Generally healthy as assessed by medical questionnaire 5) Willing and able to provide informed consent
Exclusion criteria
Exclusion criteria: 1) Medical, orthopedic, or psychiatric concern that, in the opinion of the investigators, would compromise the ability to comply with the study requirements 2) History of cancer within the last 5 years, except basal cell carcinoma, non-squamous skin carcinoma, prostate cancer or carcinoma in situ with no significant progression over the past 2 years 3) Significant orthopedic, cardiovascular, pulmonary, renal, liver, infectious disease, immune disorder, or metabolic/endocrine disorders or other disease that would affect protein metabolism 4) Current illnesses which could interfere with the study (e.g. prolonged severe diarrhea or regurgitation) 5) Subject participated in a study of an investigational product less than 60 days or 5 half-lives of the investigational product, whichever is longer, before enrollment in this study 6) Excessive alcohol consumption (>21 units/week) 7) Smoking 8) Prior gastrointestinal bypass surgery 9) History of bleeding diathesis, platelet or coagulation disorders, or antiplatelet/anticoagulation therapy 10) Use of corticosteroids, testosterone replacement therapy (ingestion, injection, or transdermal), or any anabolic steroid 11) Participation in an exercise program
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Daily muscle protein synthesis rates assessed using D2O before and after 4 weeks of fish oil supplementation | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) Muscle and blood lipid composition before, during, and after fish oil supplementation 2) Plasma markers of inflammatory state before, during, and after fish oil supplementation 3) Insulin sensitivity as assessed by oral glucose tolerance test following the ingestion of 75 g glucose before and after 4 weeks of fish oil supplementation | — |
Contacts
Public ContactStefan Gorissen
Department of Kinesiology - McMaster University
Outcome results
None listed