metabolic syndrome, diabetes mellitus
Conditions
Interventions
Sponsors
AMC-UvA
Eligibility
Inclusion criteria
Inclusion criteria: • Male sex • Caucasian • BMI >25 kg/m2 • At least 3 out of 5 NCEP metabolic syndrome criteria: fasting plasma glucose ≥5.6 mmol/l, triglycerides ≥1.7 mmol/l, waist-circumference >102 cm, HDL-cholesterol 1.04 mmol/l, blood pressure ≥130/85 mmHg • Scheduled for laparoscopic cholecystectomy or laparascopic gastric bypass • able to give informed consent
Exclusion criteria
Exclusion criteria: • A history of cardiovascular event (CVA, MI or pacemaker implantation) • Use of any medication including PPI and antibiotics in the past three months • (Expected) prolonged compromised immunity (due to recent cytotoxic chemotherapy or HIV infection with a CD4 count < 240/mm3) • Presence of overt T2D • Smoking
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| changes in postprandial translocation of intestinal bacteria between donor and own ecal transplantation. | — |
Secondary
| Measure | Time frame |
|---|---|
| changes in (small) intestinal bacterial composition related to bacterial translocation. changes in visceral and subcutaneous adipose tissue and inflammatory tone between donor and own fecal transplantation | — |
Contacts
Public ContactM. Nieuwdorp
AFDELING INWENDIGE GENEESKUNDE AMC MEIBERGDREEF 9, KAMER F4.159.2
Outcome results
None listed