Sugammadex, Train of four ratio, Respiration, Post operative
Conditions
Interventions
According to the randomization list the patient will receive at the end of the surgery sugammadex 2mg/kg or neostigmine 2.5 mg + atropine 1 mg at a NMB level of TOF>0
Sponsors
Leiden University Medical Center (LUMC)
Eligibility
Inclusion criteria
Inclusion criteria: - Age >18 years - Body mass index < 35 kg/m2 - ASA class I-III - Patients scheduled for elective surgery requiring anesthesia with the use of neuromuscular blocking agents.
Exclusion criteria
Exclusion criteria: - Known or suspected neuromuscular disorder impairing neuromuscular function - Allergie to muscle relaxants, anesthesics or narcotics. - A (family) history of malignant hyperthermia - Women who are or may be pregnant or are currently breast feeding - Contraindication for the use of neostigmine (intestinal obstruction, COPD GOLD 4 or abnormal heart rhythm) - Surgery requiring neuraxial anesthesia/analgesia - Preoperative cognitive dysfunction or mental disabilities - Preexistent significant pulmonary disease with preoperative SpO2<90% - Preoperative ICU treatment/intubation (ICU patient); - Need for postoperative ICU treatment or ventilation - Renal insufficiency (GFR<30 mL/min or oligura < 0.5 mg/kg/h)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative SpO2 level obtained at 2-min interval for 45 minutes and the need for supplemental oxygen | — |
Secondary
| Measure | Time frame |
|---|---|
| Pain, respiratory rate, sedation and lowest TOF ratio | — |
Contacts
Public ContactM Boon
LUMC, Anesthesiology, P5, Albinusdreef 2
Outcome results
None listed