Corneal disorders
Conditions
Interventions
Group 1:
Deep Anterior Lamellar Keratoplasty compared to Penetrating Keratoplasty.
Group 2:
Posterior Lamellar Keratoplasty compared to Penetrating Keratoplasty.
Sponsors
ZON-MW, The Netherlands Organization for Health Research and Development.
University Hospital Maastricht, Department of Ophthalmology
Eligibility
Inclusion criteria
Inclusion criteria: Deep Anterior Lamellar Keratoplasty: 1. Keratoconus intolerant for contact lens wear, without previous hydrops or Descemet’s rupture; 2. Stromal opacification not reaching Descemet’s membrane and without concomitant endothelial disease; 3. Best Spectacle Corrected Visual Acuity (BSCVA) < 0.4; 4. Patients who signed the informed consent.
Exclusion criteria
Exclusion criteria: Posterior Lamellar Keratoplasty: 1. Endothelial dysfunction caused by pseudophakic or aphakic corneal edema; 2. (Fuchs’) Endothelial dystrophy; 3. BSCVA < 0.4; 4. Without severe scarring of the anterior stromal cornea; 5. Patients who signed the informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Discard rate of donated corneas. | — |
Secondary
| Measure | Time frame |
|---|---|
| Visual acuity, astigmatism, stray light evaluation, contrast sensitivity, endothelial cell loss, incidence endothelial rejection, vision-related quality of life and patient satisfaction. Before operation, and at 3, 6, 12 months after operation. A full economic evaluation. | — |
Contacts
Public ContactRudy M.M.A. Nuijts
University Eye Clinic Maastricht P.O. Box 5800
Outcome results
None listed