Evening versus Morning Administration of Levothyroxine: a randomised controlled double-blind trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON26022

Enrollment

100

Registered

2007-04-17

Start date

2007-05-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

hypothyroidism, bedtime levothyroxine, quality of life Hypothyroidism --> hypothyreoidie Bedtime levothyroxine --> inname levothyroxine voor het slapengaan

Interventions

During the study, patients will have to take 2 tablets a day (one in the morning and one at bedtime), instead of 1 tablet. One of the tablets is levothyroxine, the other placebo. After 3 months the ta

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients with primary hypothyroidism; 2. Above the age of 18 years old; 3. On a stable regimen of levothyroxine for at least 6 months.

Exclusion criteria

Exclusion criteria: 1. Pregnancy; 2. Disease of the stomach; 3. Jejunum or ileum; 4. Use of medication known to interfere with the uptake of levothyroxine

Design outcomes

Primary

Measure	Time frame
Significant change in TSH and thyroid hormones FT4/T3	—

Secondary

Measure	Time frame
1 Change in: a. blood pressure; b. pulse; c. weight; d. other lab results (creatinine, lipids); 2. Change in quality of life; 3. Symptoms of hypo-or hyperthyroidism.	—

Contacts

Public ContactA. Berghout

Medisch Centrum Rijnmond Zuid, Afdeling Interne Geneeskunde

berghouta@mcrz.nl+31 10-2911911

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)