osteoarthritis, knee
Conditions
Interventions
Intra-articular injection with a high molecular weight chemically crosslinked hyaluronan polymer of avian origin (HA-polymer) will be given in total three times with a time interval of one week betwee
Sponsors
Erasmus MC
Department of Orthopedics
J.A.N Verhaar, PhD MD, Head of the department
Eligibility
Inclusion criteria
Inclusion criteria: 1. Knee pain needs to be present longer than 3 months; 2. Severity of the knee pain needs to be more than 2 mm on a VAS score; 3. Radiographic signs of knee OA needs to be present defined by a Kellgren & Lawrence score of grade 1 to 3.
Exclusion criteria
Exclusion criteria: 1. Viscosupplementation in the target knee within the last year; 2. Glucocorticoid or steroid injection into the target knee within the last three months; 3. Intra-articular procedure (arthroscopy ( 12 degrees; 11. Chondrocalcinosis; 12. Presence of hip OA severe enough to affect the evaluation of function; 13. Receiving regular analgesic therapy for reasons other than painful OA of the knee; 14. Chronic use of daily (oral) steroid therapy; 15. Alcoholism; 16. Patients from whom it is not sure that they will be able to attend the follow-up measurements; 17. Insufficient command of the Dutch language, spoken and/or written.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cost-effectiveness of 3 weekly intra-articular injections with a HA polymer added to usual care. | — |
Secondary
| Measure | Time frame |
|---|---|
| Effectiveness of 3 weekly intra-articular injections with HA polymer added to usual care. Subanalysis will be performed for severity of radiographic OA (Kellgren & Lawrence grade 1 and 2 versus grade 3). | — |
Contacts
Public ContactM. Reijman
Department of Orthopedics PO box 2040
Outcome results
None listed