Microvascular blood flow under the tongue after esophagectomy surgery and the effect of dobutamine.

Postoperative sublingual microvascular blood flow following esophagectomy and the effect of dobutamine.

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON26013

Enrollment

Registered

2010-04-10

Start date

2010-03-01

Completion date

Unknown

Last updated

2024-06-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

The intervention group will receive low dose dobutamine (max. of 2.5 µg/kg•min) during surgery or directly postoperative, whereas the control group will receive a similar volume of saline.

Eligibility

Inclusion criteria

Inclusion criteria: 1. Age range: > 18 years; 2. ASA classification I – III; 3. Written informed consent; 4. Elective esophagectomy. All inclusion criteria must be met; otherwise the patient cannot be enrolled in the study.

Exclusion criteria

Exclusion criteria: 1. Age range: < 18 years; 2. ASA classification IV and V; 3. Diabetes Mellitus (bad microvessels); 4. Administration of drugs with positive inotropic effects; 5. Patients with previous cardiac events (previous cardiac arrests and arrythmia); 6. Informed written consent missing.

Design outcomes

Primary

Measure	Time frame
The aim of our study is to observe postoperative sublingual microvascular perfusion changes in functional capillary density (FCD), perfused vessel density (PVD) and microvascular flow index (MFI), in patients undergoing esophagectomy and the effect of dobutamine intravenously.	—

Secondary

Measure	Time frame
To observe the effect of low dose dobutamine on heart rate and cardiac output.	—

Contacts

Public ContactJasper Bommel, van

PO Box 2040

j.vanbommel@erasmusmc.nl+31 (0)10 7040704

Outcome results