Thoracic epidural anaesthesia Ventricular function Bicycle ergometry
Conditions
Interventions
Thoracic epidural anaesthesia
Exercise bicycle/stress testing
Sponsors
Leiden University Medical Center (LUMC)
Eligibility
Inclusion criteria
Inclusion criteria: - Younger than 65 years - ASA 1 or 2 patients undergoing thoracic surgery under thoracic epidural anaesthesia
Exclusion criteria
Exclusion criteria: Contra-indications for thoracic epidural: • Infection of the skin in the area of the epidural site • A history of neurological diseases • A history of bleeding diathesis • Muscle diseases • Hypersensitive to local anesthetics History of Coronary Artery disease (CAD) Known decreased ejection < 40 % Known severe regurgitation or stenosis of a heart valve (grade 3 or 4) Heart rhythm other than sinus rhythm Existence of diabetes mellitus Use of B-blockers or Calcium-antagonists Pregnancy or lactation Participation in a trial on investigational drugs within 3 months prior to the study Participation in trial P14.045: “The effect of thoracic epidural anaesthesia with general anaesthesia on mean systemic filling pressure, venous return and cardiac function”.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To evaluate the HTEA effects on systolic and diastolic cardiac function in rest and after different levels of exercise. Echocardiographic variables: MV E, MV DT, MV A, MV E/A, MV S', MV A', MV E', TV E, TV A, TV E/A, TV S', TAPSE | — |
Secondary
| Measure | Time frame |
|---|---|
| To assess the difference in hemodynamic response between bicycling with and without thoracic epidural anaesthesia. Variables: HR,automated ST segment analysis by 5-lead ECG, invasive blood pressure, CO by Vigileo system | — |
Contacts
Public ContactJ. Wink
Consultant (cardiothoracic) anaesthesiology Department of Anaesthesiology LUMC, P5Q-32 2300 RC
Outcome results
None listed