aging - veroudering working memory - werkgeheugen response inhibition - respose inhibitie
Conditions
Interventions
We will measure cerebral blood flow (with fNIRS) at the prefrontal cortex, and electrical activity (with EEG) at the scalp in young and elderly healthy subjects, during the performance of a working me
Sponsors
Wageningen University, division of Human Nutrition
Eligibility
Inclusion criteria
Inclusion criteria: - Males and females aged 18-35 years (young adults group) - Males and females aged 60-75 years (older adults group) - Right-handed - Dutch speaking - Good health (see exclusion criteria) - Non-smoking (max. 1 cigarette per day) - Normal or corrected-to-normal vision - Signed informed consent available
Exclusion criteria
Exclusion criteria: - Mini-Mental State Examination (MMSE) score ¡Ü 26 (older subjects group) - Estimated IQ 3 consumptions per day) - Recurrent migraine - General medical conditions, such as repetitive strain injury (RSI), which may confound the results of the study, as judged by the investigator - Use of psychopharmacological drugs (anxiolytics, antidepressants, antipsychotic drug, long-acting benzodiazepines etc.) - Use of cardiovascular drugs (including antihypertensives) - Current participation in another study or previous participation in the fMRI study of the Donders Institute of Brain, Cognition and Behaviour, Nijmegen.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Oxygenated (O2Hb) and deoxygenated (HHb) hemoglobin concentration changes (ìmol/L), measured during baseline and the performance of the cognitive paradigm | — |
Secondary
| Measure | Time frame |
|---|---|
| - Total hemoglobin changes (O2Hb + HHb) (ìmol/L), measured during baseline and the performance of the cognitive paradigm - EEG frequency bands measured during baseline and the performance of the cognitive paradigm - Blood pressure (mmHg), measured during baseline and the performance of the cognitive paradigm - Heart rate (bpm), measured during baseline and the performance of the cognitive paradigm - Exhaled CO2 (%), measured during baseline and the performance of the cognitive paradigm - Performance on the cognitive tasks - Hospital Anxiety and Depression Scale (HADS) - Short Questionnaire to Assess Health enhancing physical activity (SQUASH) - Barratt Impulsiveness Scale (BIS-11) - Cognitive Failure Questionnaire (CFQ) (only older adults group) - Performance on the additional neuropsychological test battery | — |
Contacts
Public ContactOndine Rest, van de
Wageningen University, Division of Human Nutrition P.O. Box 8129
Outcome results
None listed