Vitamin A deficiency, bioequivalence
Conditions
Interventions
Group A: 150 mcg retinol/day
Group B: 300 mcg retinol/day
Group C: 500 mcg retinol/day
Group D: 800 mcg retinol/day
Sponsors
Wageningen University & Research
Eligibility
Inclusion criteria
Inclusion criteria: • Female • Age: 18-35 years • Non-smoking • BMI 18-25 kg/m2 • Fluent in Dutch
Exclusion criteria
Exclusion criteria: ? Pregnant or lactating ? Metabolic diseases (diabetes, hypercholesterolemia) ? Disorder or use of drugs that interferes with fat-soluble vitamin absorption ? History of chronic diseases including renal disease, liver disease, diagnosed gastrointestinal disorders and cancer ? Allergic to food that will be provided during the study ? Recent major surgery, blood transfusion or blood donation (< 6 months ago) ? Dieting or having irregular dietary habits ? Use of (multi)vitamin preparations with vitamin A or ß-carotene up till 3 months before the start of the study ? Participation in another clinical trial ? Being an MSc student or employed at the Division of Human Nutrition and Health, Wageningen University
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 13C10 isotope enrichment in plasma retinol | — |
Secondary
| Measure | Time frame |
|---|---|
| Bioconversion of 13C10-betacarotene to 13C5-retinol | — |
Contacts
Public ContactAlida Melse-Boonstra
Wageningen Universtiy & Research
Outcome results
None listed