1. Clostridium difficile
Conditions
Interventions
Arm 1: vancomycin 500 mg qid, 14 days
Arm 2: vancomycin 500 mg qid, 14 days, with a bowel lavage with kleanprep on the fourth day
Arm 3: vancomycin 500 mg qid 4 days, followed by a bowel lavage, followed by infusion of donor feces through a nasoduodenal tube on the fifth day.
Sponsors
Academic Medical Center Amsterdam
the Netherlands
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patient 18 years or older; 2. proven recurrence of Clostridium difficile associated diarrhoea (positive toxin test and diarrhoea defined as more than 3 loose or watery stools per day or >8 in 48 hours); 3. In previous episodes of Clostridium difficile associated diarrhoea at least one proper course of antibiotic therapy. (at least vancomycin 125 mg qid for 10 days or metronidazole 500 mg tid for 10 days).
Exclusion criteria
Exclusion criteria: 1. Pregnancy; 2. life expectancy of less than three months; 3. expected longlasting immunecompromised state (CD420 mg a day) expected to be prescibed for more than 30 days; 5. Need for continuous use of antibiotic other than for treatment of Clostridium difficile infection.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Diarrhoea and Clostridium difficile toxin in stool after 10 weeks. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Diarrhoea and Clostridium difficile toxin in stool after five weeks; 2. Costs; 3. Quality of life; 4. Inflammatory markers. | — |
Contacts
Public ContactE. Nood van
Postbus 22660 Department of Internal Medicine F4-222
Outcome results
None listed