Irreversible corneal endothelial failure.
Conditions
Interventions
The intervention consists of the performance of standard DSAEK or ultra-thin DSAEK.
Sponsors
Maastricht University Medical Center / University Eye Clinic Maastricht
Eligibility
Inclusion criteria
Inclusion criteria: Patients eligible for DSAEK or ultra-thin DSAEK are patients with: 1. Endothelial dysfunction caused by Fuchs’ endothelial dystrophy; 2. A minimum patient age of 18 years;
Exclusion criteria
Exclusion criteria: 1. Previous corneal transplantation; 2. Human leukocyte antigen typed keratoplasty; 3. Patients who are unable to communicate properly or to understand instructions.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary outcome measure is best corrected visual acuity (BCVA) 12 months postoperatively. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcome measures are contrast acuity, refractive and topographic astigmatism, quality of vision (measured by contrast sensitivity measurements and stray light measurements), endothelial cell loss, incidence of graft rejection, primary graft failure, cornea donor loss due to preparation, and generic and vision-related quality of life (measured by validated questionnaires). Furthermore, adverse events, including complications, will be reported for each patient. | — |
Contacts
Public ContactRudy M.M.A. Nuijts
University Eye Clinic Maastricht P.O. Box 5800
Outcome results
None listed