solitary encopresis in children
Conditions
Interventions
period 1: 1 month suppositories either placebo or loperamide twice daily 5 mg + diary chart
- combine rectal manometry and barostat at end of period
periode 2: 1 month wash-out + diary chart
perio
Sponsors
None listed
Eligibility
Inclusion criteria
Inclusion criteria: To enter the study the patients have to fulfil the following criteria: 1. Encopresis frequency of = of > 2 times / week; 2. Colonic transit time 8 yrs.
Exclusion criteria
Exclusion criteria: 1. Colonic transit time > 62 uur; 2. Other signs of constipation: a. Defecation frequency < 2 times per week; or b. Periodic passage of very large amounts of stool; or c. Palpable abdominal or rectal mass; 3. Anorectal malformations; 4. Impaired neurological functioning such as spina bifida; 5. Evident psychiatric diagnosis such as depressive disorder; 6. Metabolic diseases; 7. Using drugs influencing gastrointestinal motility; 8. Mental retardation; 9. Any abdominal or anorectal surgical intervention; 10. Hirschsprung’s disease; 11. Any other (gastrointestinal) disease with a possible influence on gastrointestinal motility.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Encopresis frequency; 2. Rectal function: comparison between loperamide and placebo period. | — |
Secondary
| Measure | Time frame |
|---|---|
| Side effects loperamide supps. | — |
Contacts
Public ContactMarc A. Benninga
Kinderarts MDL, AMC, H7-248 P.O. Box 22660
Outcome results
None listed