Depression
Conditions
Interventions
Early discontinuation versus later discontinuation of antidepressants during the one year follow-up. Although the timing of discontinuation differs between both groups, similar discontinuation schem
Sponsors
ZonMW, grant number: 80-84800-98-40002
Eligibility
Inclusion criteria
Inclusion criteria: 1. Having a stable depression remission as confirmed by absence of a DSM-5 based diagnosis of major depressive disorder during the prior 6 months, as observed in the open-label treatment cohort (OPERA-monitor) from which participants are recruited 2. Use of sertraline (50, 100, 150 or 200 mg/day) or citalopram (10, 20, 30 or 40 mg/day) 3. 18-75 years at start of antidepressant medication
Exclusion criteria
Exclusion criteria: 1. Clinically overt primary psychiatric conditions other than depression that warrant different medical attention (i.e. earlier psychosis, schizophrenia, bipolar depression, alcohol or drug addiction) 2. Insufficient mastery of the Dutch language 3. Earlier inpatient admission for depression 4. History of >3 prior MDD episodes for which treatment was started 5. Overall treatment period with antidepressants for the last depressive episode lasted more than 18 months
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes are functioning, quality of life, severity of mood, anxiety and somatic (e.g. side-effects and withdrawal) symptoms and (cost) effectiveness. | — |
Primary
| Measure | Time frame |
|---|---|
| Primary outcome is sustained remission time measured as time of follow-up without 1) severe depressive symptoms, 2) inpatient admission for depression, and 3) suicide (attempt). | — |
Contacts
Public ContactMariska Bot
Amsterdam UMC, location VUmc, Psychiatry, Amsterdam, The Netherlands
Outcome results
None listed