Apical periodontitis, pain
Conditions
Interventions
irrigation RISA
Sponsors
ACTA Dental Research B.V.
Eligibility
Inclusion criteria
Inclusion criteria: -- apical periodontitis has been diagnosed and confirmed with an intra-oral radiograph and appears on the radiograph as a radiolucent area around one or more root tips of the affected tooth. A root canal treatment has a reasonable/good prognosis (Sjögren et al. 1990) and the subject prefers NSRCT over tooth extraction or monitoring. The affected tooth has not previously received a complete root canal treatment. - no spontaneous pre-operative pain or spontaneous pre-operative pain less than 36 (see fig. 1) (Heft & Parker 1984) - no or mild swelling and no draining sinus tract on affected tooth. - 18 – 75 years. - completed the medical history questionnaire. - 1st or 2nd molar, 1st or 2nd premolar - DPSI of subject tooth is ≤3- - tooth mobility ≤1 - signed the informed consent form
Exclusion criteria
Exclusion criteria: - pain >36 on Heft-Parker VAS scale (fig. 1) - subject tooth with a mobility score 2 or more - subject tooth with a DPSI ≥3+ - subject tooth with open or incompletely formed root apices - subject tooth that requires a post - subject tooth with a vertical fracture or horizontal fracture extending below the cemento-enamel junction of the tooth - teeth in the same quadrant requiring root canal therapy - teeth with hypersensitive dentine in the same left or right facial half - absence of a periapical - previous (non)surgical (root-canal) treatment on subject tooth - draining sinus tract or exacerbation originating from affected tooth Current medication related criteria: - chronic use of pain relief medication - (par)enteral use of bisphosphonates - systemic corticoid therapy General-health related criteria: - non-odontogenic facial pain - any known infectious diseases (eg, human immunodeficiency virus, hepatitis B, hepatitis C, tuberculosis, or prion-induced disease) - history of cancer in the oral-maxillofacial region - history of cancer in the last two years - history of head and/or neck radiation therapy - diabetes mellitus type I/II, - chronic inflammatory diseases like morbus Crohn or rheumatoid arthritis - known sensitization to sorbic acid and its salts - pain >36 on Heft-Parker VAS scale (fig. 1) - subject tooth with a mobility score 2 or more - subject tooth with a DPSI ≥3+ - subject tooth with open or incompletely formed root apices - subject tooth that requires a post - subject tooth with a vertical fracture or horizontal fracture extending below the cemento-enamel junction of the tooth - teeth in the same quadrant requiring root canal therapy - teeth with hypersensitive dentine in the same left or right facial half - absence of a periapical - previous (non)surgical (root-canal) treatment on subject tooth - draining sinus tract or exacerbation originating from affected tooth  
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| pain / no pain | — |
Secondary
| Measure | Time frame |
|---|---|
| healing apical periodontitis | — |
Contacts
Public ContactS.V. van der Waal
Academisch Centrum Tandheelkunde Amsterdam,
Outcome results
None listed