Bioavailability Potatoes Anthocyanins Biobeschikbaarheid Aardappels Anthocyanen
Conditions
Interventions
Test meals 1 and 2 both weigh 500 grams and contain the same amount of potato mash, salt and oil Anthocyanin content will vary per test meal. The levels will be confirmed through samples taken for ana
Sponsors
Wageningen University
Eligibility
Inclusion criteria
Inclusion criteria: • Male • Age: 18-65 years • Body Mass Index (BMI) 18-30 kg/m2.
Exclusion criteria
Exclusion criteria: • Recent history of acute gastro-intestinal conditions (indigestion, diarrhoea, constipation) (over last 2 weeks before screening). • History of gastro-intestinal (atrophic gastritis, gastric and peptic ulcers, small bowel disease or resection, enterocolitis, Crohn’s disease, bleeding disorders) and/or renal diseases (according to research subjects own statement) • Use of supplements containing anthocyanins in the last 3 months • Use of (prescribed) medication during the whole study (excluding painkillers) • Smoking • Current participation in other studies • Having a medically prescribed diet • Working or doing an internship or thesis at the Division of Human Nutrition • Allergic or hypersensitivity for potato
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To explore the absorption of anthocyanins, changes are measured in blood plasma and urine (intact molecules and metabolite excretion products) after consumption of the different test meals. Intact molecules and main metabolites (protocatechuic acid derived, vanillic acid, vanillic acid sulfate, hippuric acid and ferulic acid) will be measured, and metabolic profiling will be used to determine other yet unknown metabolites [8, 40]. These study parameters will be monitored from t=0 to t=9 hrs after consumption of the test meal (see Figure 2 for the sampling time points). | — |
Contacts
Public ContactMarijke Hummel
Wageningen University, Division of Human Nutrition and Health
Outcome results
None listed