Metastatic liver tumors Levermetastasen
Conditions
Interventions
(partial) Magnetic Resonance-guided High Intensity Focused Ultrasound ablation of one liver metastasis
Sponsors
University Medical Center Utrecht
Eligibility
Inclusion criteria
Inclusion criteria: - At least 18 years old - Able to give informed consent - One or more metastatic liver tumor(s) - Target tumor is eligible for surgical resection - Sufficient physical condition to undergo general anesthesia or deep sedation - Waist circumference that allows positioning on the HIFU table-top inside the MR bore - Based on a clinically available CT/MRI scan, the liver tumor is potentially accessible for MR-HIFU treatment
Exclusion criteria
Exclusion criteria: - Contra-indication for MRI scanning - Contra-indication to injection of gadolinium-based contrast agent, including known prior allergic reaction to any contrast-agent, and renal failure (defined as GFR < 30mL/min/1.73m2) - Patients who prefer not to be informed about unexpected MRI findings - Surgical clips or considerable scar tissue in the HIFU beam path - Past or future other loco-regional therapies for the same tumor (that is to be treated with MR-HIFU ablation) until the moment of surgical resection, such as (but not restricted to) RF ablation, microwave ablation, cryoablation, chemo-embolization, radio-embolization, or radiotherapy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Correspondance of the ablated volumes on MR thermometry (obtained per-procedural), MR imaging (obtained post-procedural), and histopathology (obtained from resection specimen) | — |
Secondary
| Measure | Time frame |
|---|---|
| Safety (adverse events, liver function tests) | — |
Contacts
Public ContactJ. Wijlemans
UMC Utrecht, afd. Radiologie Postbus 85500, 3508GA
Outcome results
None listed