Influence of RYANodyne receptor 1 mutations On Pulmonary arterial Pressure And ventilation During isocapnic hypoxia.

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON25834

Enrollment

Registered

2011-02-17

Start date

2011-05-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Malignant hyperthermia hypoxia hypoxic ventilatory response hypoxic pulmonary vasoconstriction

Interventions

One hypoxic period of 1 hour.

Eligibility

Inclusion criteria

Inclusion criteria: Healthy Malignant Hyperthermia patients with a phenotypic high susceptibility and a proven causative mutation. The major inclusion criteria are that the subject has echo evidence of tricuspid regurgitation during systole, which is not clinically relevant but in fact can be demonstrated in most normal individuals.

Exclusion criteria

Exclusion criteria: 1. Obesity (BMI > 30); 2. Presence of medical disease: heart-, lung-, liver-, kidney- and lung disease; diabetes; 3. Presence of psychiatric disease: A. History of chronic alcohol or drug use; B. Possibility of pregnancy; C. Lactation.

Design outcomes

Primary

Measure	Time frame
1. Systolic PAP; 2. HVR.	—

Secondary

Measure	Time frame
1. Systolic and diastolic cardiac functions; 2. Vital and ventilatory parameters.	—

Contacts

Public ContactRob Lindeman

Department of Anesthesiology LUMC, P5-Q

c.r.lindeman@lumc.nl+31 (0)71 5262301

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)