Sodium Bicarbonate for the prevention of contrast induced nephropathy in patients suspected with acute pulmonary embolism undergoing CTPA.

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON25804

Enrollment

264

Registered

2009-08-18

Start date

2009-07-09

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Contrast Induced Nephropathy (contrastnefropathie) CT-pulmonary angiography (CTPA) Sodium bicarbonate (natriumbicarbonaat) Prevention (preventie)

Interventions

1. Sodium Bicarbonate 1 hour prior to CTPA 1 ml/kg bodyweight

2. CTPA without any hydration.

Eligibility

Inclusion criteria

Inclusion criteria: Clinical suspected PE with an indication for CT-PA with intravenous administration of iso-osmolair contrast media and eGFR < 60 ml/min.

Exclusion criteria

Exclusion criteria: 1. Age < 18 years; 2. Exposure to contrast media within 7 days; 3. Pregnancy; 4. Allergy to contrastmedia; 5. Systolic bloodpressure < 100 mmHg.

Design outcomes

Primary

Measure	Time frame
Mean increase in serumcreatinine 2-4 days after CT-PA.	—

Secondary

Measure	Time frame
1. Increase in serum creatinine > 25% or > 44 umol/l, 3 days (+/- 1 day) after CT-PA with contrast media; 2. Increase in serum creatinine >25% or > 44 umol/l 2 months after CTPA with contrast media or the need for dialysis; 3. Increase in C-cystatine and NGAL 3 days (+/- 1 day) after CT-PA; 4. Increase in NGAL 2 hours after CT-PA.	—

Contacts

Public ContactJudith Kooiman

Leiden University Medical Center, Albinusdreef 2, Postzone C4-70

j.kooiman@lumc.nl+31 (0)71-526.20.85

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)