pulmonary embolism, longembolie
Conditions
Interventions
Subjects presenting at the emergency department with suspected acute pulmonary embolism and either increased D-dimer or Wells-score, will be asked to breathe normally into the Aeonose while wearing a
Sponsors
Medisch Spectrum Twente
Eligibility
Inclusion criteria
Inclusion criteria: - Adult (>= 18 years) subjects on the emergency department with suspected pulmonary embolism - CTPA scan scheduled due to suspected pulmonary embolism - Being able to read, write and understand Dutch - Informed consent obtained
Exclusion criteria
Exclusion criteria: - No CTPA scan performed - Indeterminate CTPA scan results - No Wells-score and D-dimer available - Hemodynamic instability - Being unable to perform Aeonose measurement - Being unable to read, write or understand Dutch - No informed consent obtained prior to the breath analysis - Breath analysis performed after the CTPA scan - Breath analysis performed after start of treatment of pulmonary embolism - Diagnosis of pulmonary embolism within a period of 3 months after the visit to the emergency department where PE was excluded on CTPA
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Diagnostic accuracy for the Aeonose to detect acute pulmonary embolism compared to computed tomography pulmonary angiography | — |
Secondary
| Measure | Time frame |
|---|---|
| - Differences in diagnostic accuracy for the Aeonose to detect acute pulmonary embolism compared to computed tomography pulmonary angiography for different locations and extent of the pulmonary emboli. - Differences in diagnostic accuracy of the Aeonose in detecting PE in the presence of several comorbidities. - The diagnostic accuracy of the Aeonose in predicting risk stratification of PE according to validated risk stratification scores (such as the Pulmonary Embolism Severity Index) | — |
Contacts
Public ContactT.M. Fabius
Outcome results
None listed