Cancer cachexia Spierverlies bij kanker
Conditions
Interventions
All interventions will be performed before and after 18 weeks of chemotherapy:
1. Maximal strength assesment
2. Maximal cycling test
3. Muscle biopsy from the vastus lateralis muscle
4. Venous blood sample
5. Dexa scan
6. Questionnaires regarding physical activity, dietary status and quality of life.
Sponsors
Maxima Medisch Centrum, Veldhoven
Eligibility
Inclusion criteria
Inclusion criteria: 1. Female breast cancer patients; 2. Age between 30-65 years; 3. 18 weeks of chemotherapy treatment with TAC.
Exclusion criteria
Exclusion criteria: 1. Participation in an exercise rehabilitation program during the study; 2. Chronic diseases that influence skeletal muscle characteristics, like type II diabetes mellitus, chronic obstructive pulmonary disease, chronic heart failure; 3. Chronic inflammatory disorders, like rheumatoid arthritis, colitis ulcerosa or Crohn's disease; 4. Musculoskeletal disorders that cause an inability to perform exercise.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in muscle mass, measured with dexa scan and fiber cross sectional area in muscle biopsy from the vastus lateralis muscle. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Changes in muscle strength; 2. Changes in endurance capacity; 3. Changes in markers of systemic inflammation and metabolism; 4. Changes in physical activity, diet and quality of life. | — |
Contacts
Public ContactM. Beelen
Maxima Medisch Centrum De Run 4600
Outcome results
None listed