Neural mechanisms of oxytocin

Neural mechanisms of oxytocin in human social - emotional behaviour

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON25752

Enrollment

Registered

2008-09-24

Start date

2009-01-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

fundamental study in underlying mechanisms of social behaviour

Interventions

Participants will self-administer 24 IU OT nasal spray. This nasal spray contains a synthetic version of OT which is identical to the human pituitary version of OT under the registered name Syntocinon

Kosfeld et al., 2005).

Eligibility

Inclusion criteria

Inclusion criteria: 1. Good health 2. Age between 18 and 30 3. Normal or corrected to normal vision 4. Right-handedness

Exclusion criteria

Exclusion criteria: 1. Oversensitivity for OT or carrier 2. Use of psychotropic medication, or of recreational drugs over a period of two weeks prior to each experiment, and no use of alcohol within the last 24 hours before each measurement. 3. Habitual smoking 4. History of psychiatric treatment or current psychiatric treatment 5. History of neurological treatment or current neurological treatment 6. History of endocrinological treatment or current endocrinological treatment 7. Irremovable ferrous objects in or around the body (e.g. pacemaker, stents, splinters) 8. History of closed head injury 9. History of epilepsy 10. Claustrophobia

Design outcomes

Primary

Measure	Time frame
Differences in blood oxygen level dependent (BOLD) response between OT administration and placebo will be measured.	—

Secondary

Measure	Time frame
2 questionaires will be obtained	—

Contacts

Public ContactP.A. Bos

University Utrecht

p.a.bos@uu.nl

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)