hemodialysis (disturbed) circadian rhythm
Conditions
Interventions
None listed
Sponsors
Meander Medical Center
Eligibility
Inclusion criteria
Inclusion criteria: Hemodialysis patients: 1. Stable chronic hemodialysis patients; 2. Written informed consent; 3. Age 18-85 years; 4. Good understanding of Dutch language. Control patients: 1. Stable patients; 2. MDRD-GFR > 60 ml/min; 3. Age and gender matched with hemodialysis patient; 4. Written informed consent; 5. Age 18-85 years; 6. Good understanding of Dutch language.
Exclusion criteria
Exclusion criteria: 1. Blindness; 2. Fever >38ºC; 3. CRP > 20 mg/L; 4. Use of hypnotics during study period; 5. Anesthesia within 48 hours prior to start study measurements; 6. Serious co-morbidity that prevents participation in this study according to the investigators (e.g. neurological, psychiatric, blindness, angina, heart failure NYHA class IV).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Establish 24-hr peripheral clock gene and clock controlled output gene expression profiles in blood of hemodialysis patients compared to control subjects to diagnose renal disease mediated circadian disruption. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Investigate the clock synchronization and phase-shifting potential of serum from chronic kidney disease patient and control groups. Renal patients are expected to have high levels of clock resetting compounds; 2. Determine the correlation between clock gene expression and sleep as a physiogical read-out of clock-driven behaviour. | — |
Contacts
Public ContactM. Russcher
Meander Medical Centre dept. Hospital Pharmacy PO Box 1502
Outcome results
None listed