None
Conditions
Interventions
Repeated UVR exposure of the back skin during 5 days (Monday to Friday). The UVR dose on the sunscreen protected skin will be 150 mJ/cm2 (approximately 5 MED). Two different sunscreens with a declared
Sponsors
None
Eligibility
Inclusion criteria
Inclusion criteria: - Between 18 and 65 years of age - Fitzpatrick skin type II or III - Free of any dermatological or systemic disorder which would interfere with the results, at the discretion of the investigator - Individual who has read, understood, and signed an informed consent document relating to the specific study to which he/she is subscribing - Willingness to actively participate in the study and come to the scheduled visits - Willingness to discontinue the use of detergents (e.g. soaps) and cosmetics products (e.g. creams, moisturizers) in the treatment area throughout the course of the study - Willingness to avoid any exposure of the test area to artificial or natural ultraviolet light throughout the course of the study - Individual with no known abnormal response to sunlight (e.g. polymorphic eruption) or to sunscreen (ingredients of sunscreen)
Exclusion criteria
Exclusion criteria: - Taking medication which in the opinion of the investigator would mask or interfere with the results - With chronic skin allergies - With suntan of sunburn - Breastfeeding - Pregnancy or the intention to become pregnant over the duration of the study - Participation in, or being in the waiting period for another study - Individual with moles, tattoos, scars, irritated skin, hairs, etc. at the test area that could influence the investigation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Urocanic acid isomers, immunological mediators, and angiogenesis factors in the stratum corneum at baseline and after UVR. | — |
Contacts
Public ContactAnne Keurentjes
Amsterdam UMC, locatie AMC
Outcome results
None listed