Breast Cancer
Conditions
Interventions
1) dietary energy restriction (-30% from habitual intake), 2) daily exercise (30 min cycling at 70% HRmax, 30 min full body resistance-type exercise, 30 min walking).
Sponsors
Maastricht University
Eligibility
Inclusion criteria
Inclusion criteria: 1) Female 2) BMI 20-35.0 kg/m2 3) Diagnosed with breast cancer, with treatment requiring a lumpectomy or mastectomy
Exclusion criteria
Exclusion criteria: 1) Patients receiving preoperative chemo- or radio-therapy 2) >5% weight loss in the previous 6 months 3) Fasting glucose >7 mmol/L 4) Musculoskeletal injuries (which may interfere with performing the exercise program) 5) Participation in structured resistance exercise program 6) A history of neuromuscular problems 7) Use of anti-coagulants 8) Use of protein and/or fish-oil supplements 9) Participation in a 2H2O study in the previous 6 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Tumor tissue protein synthesis rates over the 7-day intervention period in breast cancer patients. 2. Muscle tissue protein synthesis rates over the 7-day intervention period in breast cancer patients. | — |
Secondary
| Measure | Time frame |
|---|---|
| Differences between intervention groups in concentrations of circulating anabolic hormones (e.g., estrogen, insulin, growth hormone), growth factors (e.g., IGF-1, IGFBP-1, IGFBP-3), and (pro- and anti-inflammatory) cytokines (e.g., C-reactive protein, IL-1, IL-6, TNF-alpha, IL-10). | — |
Contacts
Public ContactAndrew Holwerda
Maastricht University
Outcome results
None listed