The effect of thoracic epidural anaesthesia with general anaesthesia on mean systemic filling pressure, venous return and cardiac function

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON25658

Enrollment

Registered

2014-08-10

Start date

2014-08-15

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

TEA means systemic filling pressures arterial- and venous resistance cardiac output fluid loading vasopressor

Interventions

thoracic epidural anaesthesia with general anaesthesia

Eligibility

Inclusion criteria

Inclusion criteria: All adult patients scheduled for lung surgery under thoracic epidural and general anaesthesia

Exclusion criteria

Exclusion criteria: • Participation in a trial on investigational drugs within 3 months prior to the study • Hemodynamic instability prior to start of measurements with the systolic blood pressure decreasing more than 30% below the pre-anaesthetic value or a mean arterial pressure (MAP) 18 mm Hg and/ or a cardiac index < 2.0 L•min-1 or dependence on high dosages of inotropic drugs after induction of general anaesthesia and before TEA. • Severe arrhythmias • Intra-cardiac shunts • Prior diagnosis of aberrant cardiovascular anatomy • Symptomatic peripheral vascular disease • Severe chronic obstructive pulmonary disease (GOLD III or IV, or proven existence of lung bullae) • Clinically significant aortic aneurysm • Significant valvular regurgitation • Use of lithium medication • Diabetes requiring insulin therapy • On beta blocker or calcium antagonist medication • Contra-indications to epidural anaesthesia: - Increased risk of bleeding induced by medication or bleeding disorders - Local infection at the insertion site - Anatomic abnormalities of the spine

Design outcomes

Primary

Measure	Time frame
-To evaluate the effects of thoracic epidural anaesthesia (TEA) under general anaesthesia on mean systemic filling pressures, arterial- and venous resistance and cardiac output	—

Secondary

Measure	Time frame
- To assess the hemodynamic effects of vasopressors and fluid loading under TEA with general anaesthesia conditions - To assess the value of stroke volume variation and pulse pressure variation,to predict fluid loading responsiveness with TEA.	—

Contacts

Public ContactJ. Wink

Consultant (cardiothoracic) anaesthesiology Department of Anaesthesiology LUMC, P5Q-32 2300 RC

j.wink@lumc.nl+31 (0)71 5262301

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)