stroke
Conditions
Interventions
Treatment with high dose paracetamol (6 g/day) or placebo will start within 12 hours after onset of symptoms, and continue for 3 days.
Sponsors
None listed
Eligibility
Inclusion criteria
Inclusion criteria: 1. Clinical diagnosis of acute stroke 2. Possibility to start treatment within 12 hours from onset 3. Brain CT or MRI within 24 hours 4. Age 18 years or older 5. Signed informed consent
Exclusion criteria
Exclusion criteria: 1. A body temperature lower than 36 degrees Celsius or higher than 39 degrees Celsius 2. A history of liver disease 3. Alcohol abuse 4. Liver enzymes increased above twice the upper limit of normal 5. Allergy to paracetamol 6. Significant pre-stroke impairment (³3 on the modified Rankin Scale (mRS))
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome measure is the dichotomized mRS (¡Ü2: good outcome, ¡Ý3: poor outcome) at 3 months. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary endpoints are the score on the Barthel index after two weeks, body temperature after 24 hours of treatment, and the EuroQol-5D at 3 months. | — |
Contacts
Public ContactH. Hertog, den
Erasmus Medical Center Department of Neurology, Suite Ee 2240 P.O. Box 2040
Outcome results
None listed