osteoarthritis
Conditions
Interventions
For a period of 12 weeks one group receives a daily capsule containing eggshell membrane, and the other group daily receives a placebo capsule.
Sponsors
JLK Nutrition
Eligibility
Inclusion criteria
Inclusion criteria: • Age between 40-75 • NRS pain of 3 or more • Diagnosed with osteoarthritis of the knee (confirmed by Health Care Professional) • Able to understand, read, and write Dutch • Daily access to e-mail and internet • Non-smoking • Signed informed consent • Willing to comply with study procedures
Exclusion criteria
Exclusion criteria: • NRS pain of 9 or 10 • Use of supplements aimed to target specifically osteoarthritis and/or rheumatoid arthritis (including glucosamine, chondroitin, collagen, MSM, green lip mussel, Boswelia extract or the-like) within 2 months prior to the start of the study • Known allergy to eggs or egg products • Pregnant or breastfeeding women • Previously enrolment in a study to evaluate pain relief within the past 6 months or currently involved in any other research study involving an investigational product (drug, device, or biologic) or a new application of an approved product
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Main study endpoint includes assessment of self-reported pain (0-10) on a Numerical Rating Scale (NRS pain) after 6 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary endpoints include assessment of self-reported pain (0-10) on a Numerical Rating Scale (NRS pain) after 12 weeks, as well as self-reported stiffness and function/health through Knee injury and Osteoarthritis Outcome Scores (KOOS) on days 42 and 84. | — |
Outcome results
None listed