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Conditions
Interventions
Subjects will fill in questionnaires and perform cognitive tasks during three visits in this study. In addition, subjects will receive an invitation to a brief online questionnaire concerning depressi
Sponsors
University Medical Center Groningen
Eligibility
Inclusion criteria
Inclusion criteria: -Age between 18 and 35 years -Caucasian ethnicity -Heterosexual -Right-handed -Dutch as a native language -Dissolution of a romantic relationship in the preceding two months at the time of giving written informed consent -Relationship duration (prior to breakup) of at least six months
Exclusion criteria
Exclusion criteria: -Presence of a neurological disorder (such as epilepsy) -Presence of a psychiatric disorder -Vision problems that cannot be corrected -Not able to undergo 3 Tesla MRI scanning
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcomes are listed for each of our six objectives. (1) Major Depression Inventory (MDI) scores, measured every two weeks (2) cognitive control ability, measured three times during the study (3) neural processing of reward and punishment during the MID task in the fMRI scanner (4) brain activity and functional connectivity (FC) during resting-state fMRI scanning, (5) rumination scores and resting-state FC data (6) resting-state fMRI data collected both before and after the task-based fMRI scanning session. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes will be trait rumination, degree of neuroticism and behavioral performance during the MID task. | — |
Contacts
Public ContactA.M. Verhallen
UMCG
Outcome results
None listed