inoperable oesophageal tumors definitive chemoradiation dose escalation
Conditions
Interventions
An increase of the radiation dose of on the primary tumor, from the standard dose of 50,4 Gy in daily fractions of 1.8 Gy, to 61.6 Gy in fractions of 2.2 Gy. The dose escalation will be administered w
Sponsors
dept of Radiotherapy, AMC, Amsterdam
Arhems Radiotherapeutisch Institute, Arnhem
dept of oncology, Erasmusmc, Rotterdam
Eligibility
Inclusion criteria
Inclusion criteria: 1. T1-4, N0-3,M0 medically or technically inoperable esophageal or junction tumors; 2. Histology proven; 3. WHO 0-2; 4. Tumor 18; 6. Informed consent.
Exclusion criteria
Exclusion criteria: 1. Esophageal fistula; 2. Both pathological nodes at supraclavicular and truncus coeliacus level; 3. Junction tumors with supraclavicular nodes histology other than squamous-, adeno- or large cell carcinoma; 4. Extensive CIS of the esophagus outside the planned RT field; 5. Esophageal stent; 6. Secondary malignancies other than bcc of the skin and DCIS of breast/cervix uteri; 7. Severe heart of neurologic disease.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Local tumor control in the esophagus. Measured by anamnesis at 1, 2, 5, 8, 12, 18, 24, 36, 48 and 60 months, and by CT scans at 2, 8 and 18 months. Endoscopy and PET CT scan will be performed on indication. | — |
Secondary
| Measure | Time frame |
|---|---|
| Survival and grade 3-4 toxicity, measured at the same interval as local tumor control using an oesofagus toxicity form. | — |
Contacts
Public ContactM.C.C.M. Hulshof
Dept of Radiotherapy Meibergdreef 9
Outcome results
None listed