atherosclerosis, MR Imaging, biomarkers, presence, progression, young adults
Conditions
Interventions
Questionnaire: to obtain information regarding age, gender, race, medical history, medication use and lifestyle (smoking, alcohol consumption, dietary intake and social economic status),
Physical exa
Sponsors
University Medical Center Utrecht
Eligibility
Inclusion criteria
Inclusion criteria: no medical history of cardiovascular disease and no cardiovascular preventive medication; between 25-35 years of age; willing and be able to sign informed consent
Exclusion criteria
Exclusion criteria: subjects with claustrophobia; subjects with a history of allergic reactions to MR contrast fluids; subjects with implanted electronic devices (i.e. pacemaker, internal cardioverter-defibrillator, cochlear implants, nerve- and bone stimulators); subjects with ferromagnetic clips in brain, eyes or lungs; subjects with a known reduced kidney function (GFR< 60 ml/min) subjects who are pregnant
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| (a) presence and (b) rate of change in atherosclerosis over time in young adulthood (visualized with state-of the-art magnetic resonance imaging techniques) predicted by certain biomarkers of circulating cells and systemic inflammation | — |
Secondary
| Measure | Time frame |
|---|---|
| aortic wall thickness and volume; presence and number of aortic atherosclerotic plaques (luminal protrusion of > 1 mm in radial thickness); the extent of aortic atherosclerosis (expressed as % of affected aorta as fraction of total aorta depicted) | — |
Contacts
Public ContactA.L.M. Eikendal
Department of Radiology University Medical Center Utrecht Room E.01.132 Heidelberglaan 100
Outcome results
None listed