n.a. healthy research subjects
Conditions
Interventions
Tomatoes, GABA supplement, Glutamate supplement, Placebo
Sponsors
Wageningen University and Research
Eligibility
Inclusion criteria
Inclusion criteria: - BMI between 18.5 and 25 kg/m2 - Age is between 18 and 28 years - Good general health - Male - Veins suitable for blood sampling - Able to speak Dutch
Exclusion criteria
Exclusion criteria: - Is currently suffering from a disease including mental disorders - Has had any gastrointestinal condition/disease within the 3 months prior to the intervention - Haemoglobin (Hb) level 2 kg in the month prior to the intervention - Use of dietary supplements, 3 weeks before-, or during the intervention. - Allergic to products that are provided as part of the standardised diet - Unwilling to consume the products that are part of the standardised diet - Allergic to tomatoes - (History of) drug abuse, in this case meaning >1 x per month use of recreational drugs - Smoking - Alcohol consumption of >10 standardised glasses per week. - Not able to refrain from alcohol consumption 2 days before each test day - Recent or planned blood donation (<3 month prior to first study day or during intervention) - Personnel of Wageningen University, department of Human Nutrition and Health, - Currently participating in other research or was participating in another study within 1 month of the intervention or within 3 months if invasive procedures were used.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameter is the plasma-time curve of GABA after intake of a GABA supplement and tomatoes. This will be studied using descriptive kinetics (maximum peak height (Cmax), time-to-peak (Tmax), Half-life (T1/2) and area-under-the-curve (AUC)). | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary study parameters are: - The plasma-time curves of glutamate in response to a glutamate supplement and tomatoes. - The plasma-time curves of GABA in response to a glutamate supplement in comparison to the plasma time-curves of GABA after tomato intake. | — |
Contacts
Public ContactTessa de Bie
Wageningen University
Outcome results
None listed