GERD Gastro-esophageal reflux disease GORZ gastro-oesofageale reflux ziekte
Conditions
Interventions
1. The use of proton pump inhibitors has to be stopped 5-7 days prior to the study day
2. On the study day, 350MBq Tc-pertechnetate is injected intravenously
3. Randomized single oral administration of either 10 mL Gaviscon (Indium-labelled) or 10 mL Antagel
4. Esophageal high-resolution manometry/pH-manometry to detect reflux eipsodes during 2 postprandial hours
5. Scintigraphy.
Sponsors
Prof. dr. G.E. Boeckxstaens
Academic Medical Center
Eligibility
Inclusion criteria
Inclusion criteria: 1. GERD confirmed by pH-impedance (ph 4,5 % of time or positive symptom association), or in patients with reflux esophagitis; 2. Written informed consent; 3. 18-75 years.
Exclusion criteria
Exclusion criteria: 1. Surgery of the gastrointestinal tract other than appendectomy; 2. Inability to stop the use of proton pump inhibitors for one week; 3. Participation in another study with exposure to radiation; 4. Participation in another study within the last year; 5. Long segment of Barrett’s epithelium.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary outcome is the number of acid reflux episodes detected on pH-impedance measurements. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes are postprandial esophageal acid exposure, the rate of acid versus non acid reflux events, the number of non acid reflux events and the position of the acid pocket, relative to the crural diaphragm. | — |
Contacts
Public ContactG.E.E. Boeckxstaens
Academic Medical Center (AMC), Department of Gastroenterology, C2-328, P.O. Box 22660
Outcome results
None listed