Experimental gingivitis model Probiotics Bleeding on marginal probing Microbiome Oral health Probiotica Mondgezondheid Tandvleesontsteking
Conditions
Interventions
3 times daily intake of probiotic lozenges during 4 weeks
two weeks no dental cleaning (brushing)
Sponsors
Ir. W. Th. Fokkema
ACTA Dental Research B.V. (ADR)
Gustav Mahlerlaan 3004
1081 LA Amsterdam, NL
w.fokkema@acta.nl / +31 6 28 724 788
Eligibility
Inclusion criteria
Inclusion criteria: 1. Willing and able to give written informed consent and willing and able to comply to all study procedures; 2. Adult, ≥ 18 years - 55 years; 3. Male and female; 4. Systemically healthy, as assessed by a medical questionnaire (no systemic diseases); 5. Minimum of 20 natural teeth: at least the first or second molar must be present in each quadrant; 6. Having visited the dentist for a regular check-up within the last year and having finished the necessary treatment(s);
Exclusion criteria
Exclusion criteria: 1. Not meeting the inclusion criteria; 2. ACTA dental student or ACTA employee; 3. Participation in a clinical study within the previous 30 days; 4. Allergy/Intolerance to the test and placebo products (ingredients) in particular lactose and milk protein content (allergens) in the test products; General health and use of medication: 5. Smokers, definition non-smoker: <1 cigarette every day for at least one year (e-cigarettes will also be excluded); 6. Abuse of drugs or alcohol; 7. Self-reported pregnancy or breastfeeding; 8. Use of antibiotics during the last 3 months; 9. Need of antibiotic prophylaxis prior to dental treatment; 10. Use of anti-inflammatory drugs on a regular basis; 11. Evidence of any systemic disease or compromised health condition, including: a. Diabetes mellitus; b. Bronchitis, tonsillitis or sinusitis; 12. Severe oral- or pharyngeal infections; 13. Current disorders/disease resulting in (self-induced) vomiting; 14. Reduced salivary flow due to pathological reasons (e.g., Sjögren syndrome); 15. Adverse medical history or long-term medication; 16. Prescribed medication (except for contraceptives); 17. Willing not to consume any other probiotic or yoghurt products during the study;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Bleeding on marginal probing | — |
Secondary
| Measure | Time frame |
|---|---|
| Microbiome composition | — |
Contacts
Public ContactS.V. van der Waal
Academisch Centrum Tandheelkunde Amsterdam,
Outcome results
None listed