All the people, who have had an childhood empyema since 1985, will be included. The patients must have been admitted in the VU hospital or AMC hospital, which are both in Amsterdam, and they must have had a surgical operation, such as video assisted thoracoscopic surgery, decortication or thoracotomy. At the moment of follow up they have to be 6 years or older.
Conditions
Interventions
1 pulmonary function test and 1 excersice taking 4-5 hours of time.
Sponsors
VU medical centre (Amsterdam); see scientific contact
Eligibility
Inclusion criteria
Inclusion criteria: 1. The childhood empyemas treated by surgery must suffice the next criteria: 'febrile illness with pulmonary dysfunction', 'accumulation of fluid in the pleural space on X-thorax or ultrasound' and 'purulent fluid in pleural space or signs of loculations on X-thorax or ultrasound/ WBC count > 15.000/microl; 2. Patients have undergone video assited thorocoscopic surgery, decortication or thoracotomy.
Exclusion criteria
Exclusion criteria: 1. Phase 1 empyemas; 2. Empyemas caused by trauma, surgery (other than interventional surgery) or tbc; 3. Mental retardation, age <6 years or chromosomal disease (cannot do pulmonary function testing); 4. Prematurity (<32 weeks), other lung diseases, such as cystic fibrosis, lung resections and asthma.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary study parameters of the pulmonary function test: 1. Total lung capacity (TLC); 2. FEV1/VC; Primary study parameter of the exersize test: 3. VO2 max. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secundary study parameters of the pulmonary function test: 1. Forced vital capacity (FVC); 2. FEV1; 3. Maximal mid-expiratory flow (MMEF25-75%); 4. Residual volume (RV); 5. Diffusion capacity. Secundary study parameters of the exersize test: 6. Heart frequenty max. (HF max.); 7. Max. exercise ventilation/max. voluntary ventilation; 8. Max. tidal volume/inspiratorycapacity (Vt max/IC); 9. O2 pulse; 10. SO2; 11. Respiratory quotiënt (VCO2/VO2). | — |
Contacts
Public ContactH.A. Heij
Academic Medical Center (AMC), Emma Children's Hospital and VU University Medical Center, Department of Pediatric Surgery (9d32), P.O. Box 22660
Outcome results
None listed