Pharmacokinetics of Paracetamol before and after Roux-en-Y gastric bypass

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON25518

Enrollment

Registered

2020-01-11

Start date

2020-02-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Morbidly obesity

Interventions

Single oral dose of PCM 1000 mg

Eligibility

Inclusion criteria

Inclusion criteria: - At least 18 years old - On the waiting list of getting a RYGB - Mentally competent - Provided informed consent

Exclusion criteria

Exclusion criteria: - Undergoing different types of bariatric surgery, such as gastric band, gastric sleeve, mini gastric bypass or revision RYGB - Previously undergone a gastric surgery, such as gastric band, RYGB or gastric sleeve - Liver failure - Taken PCM < 24h before blood sampling at t=0 - Allergy or intolerance for PCM - Not being able to take PCM orally

Design outcomes

Primary

Measure	Time frame
Pharmacokinetics of paracetamol after a single oral dose of 1000 mg before and after RYGB	—

Secondary

Measure	Time frame
Pharmacokinetics of the metabolites paracetamol glucuronide, paracetamol sulfate, paracetamol mercaptopurate and paracetamol cysteïne. Additional secondary end points are aspartate aminotransferase, alanine aminotransferase, gamma-glutamyltransferase and bilirubin values before, after 6h and 24h after a single oral dose of 1000 mg PCM before and after RYGB.	—

Contacts

Public ContactCedric Lau

Albert Schweitzer ziekenhuis

s.f.lau@asz.nl0786523213

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)