Cognitive decline Depression
Conditions
Interventions
1. 400 mg EPA-DHA in capsules
2. 1.8 g EPA-DHA in capsules
3. Placebo oil in capsules.
Sponsors
Wageningen University (Division of Human Nutrition):
Ir. O. van de Rest
Dr. Ir. L.C.P.G.M. de Groot
Dr. J.M. Geleijnse
Prof. Dr. Ir. F.J. Kok
Prof. W.A. van Staveren
University Medical Centre / Radboud University Nijmegen (Geriatrics):
Prof. Dr. W.H.L. Hoefnagels
Free University Amsterdam (Psychiatrics):
Prof. Dr. A.T.F. Beekman
Eligibility
Inclusion criteria
Inclusion criteria: 1. Men and women; 2. Aged 65 years and over; 3. Informed consent signed.
Exclusion criteria
Exclusion criteria: 1. A score of > 16 on the CES-D (Centre for Epidemiological Studies-Depression Scale; 2. A score of < 21 points on MMSE (Mini-Mental State Examination); 3. Current or recent (<4 weeks) use of fish oil supplements or intake of more than 4 times fish/ week; 24.35 g of EPA-DHA from fish per month (800 mg/day) as judged by a fish consumption questionnaire; 4. Current use of pharmacological antidepressants; 5. Current use of dementia (Alzheimer) medication; 6. Serious liver disease; 7. Use of more than 4 glasses of alcohol per day; 8. Unable to participate as judged by the responsible medical physician; 9. Allergy to fish(oil); 10. Swallowing problems; 11. Participation in another clinical trial less than 2 months before the start of the trial or at the same time.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cognitive function and mental well-being. | — |
Secondary
| Measure | Time frame |
|---|---|
| Quality of life. | — |
Contacts
Public ContactOndine Rest, van de
Wageningen University, Division of Human Nutrition P.O. Box 8129
Outcome results
None listed