The influence of cocaine and cannabis on impulsivity.

Cognitive and motor impulsivity in regular cannabis and cocaine users as a function of COMT and DBH genotype.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON25495

Enrollment

Registered

2009-12-01

Start date

2010-01-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cannabis cocaine impulsivity impulsiviteit genotypering genotyping dopamine COMT DBH

Interventions

1. Cocaine HCl 300mg as capsule

2. Cannabis 20mg by inhalation

3. Placebo.

Eligibility

Inclusion criteria

Inclusion criteria: 1. Regular use of cannabis and cocaine; 2. Good physical and mental health; 3. Body weight between 80 and 130% of the ideal bodyweight as defined in the Metropolitan Life Insurance tables; 4. Age 18-40.

Exclusion criteria

Exclusion criteria: 1. Pregnancy or lactation; 2. Cardiovascular abnormalities as assessed by standard ECG; 3. Excessive drinking; 4. Hypertension; 5. History of psychiatric and neurological disorders.

Design outcomes

Primary

Measure	Time frame
The influence of cocaine and cannabis on impulsivity modulated by COMT and DBH genotypes. Genotyping of DBH will be performed before inclusion, COMT after testing.	—

Secondary

Measure	Time frame
Outcomes on: 1. Matching familiar figures; 2. Stop-signal task; 3. Tower of London; 4. CTT/DAT; 5. Attentional Switch task; 6. Prospective memory task; 7. Cued Go/NoGo task.	—

Contacts

Public ContactJ. Wel, van

Postbus 616

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)