Vruchtbaarheid, eicelvoorraad en vervroegde overgang bij Nederlandse vrouwen die in hun jeugd kanker hebben gehad .

Reproductive function, ovarian reserve and risk of premature menopause in Dutch female childhood cancer survivors.

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON25491

Enrollment

2000

Registered

2011-05-31

Start date

2006-12-01

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

childhood cancer , fertility, ovarian reserve, premature menopause

Interventions

Questionnaire, provision of a blood sample, and transvaginal ultrasound measurement of the reproductive organs.

Eligibility

Inclusion criteria

Inclusion criteria: 1. Female; 2. Treated for malignancy or a central nervous system tumour before the age of 18; 3. Treated between 1965 and 2001, 5-year survivors; 4. At least 18 years at study entry.

Exclusion criteria

Exclusion criteria: 1. Being unable to speak or read Dutch; 2. Having severe mental sequelae; 3. Being pregnant or lactating at time of study.

Design outcomes

Primary

Measure	Time frame
1. Questionnaire part: Reproductive history, pregnancy outcomes, menopausal symptoms and menopause; 2. Clinical part: FSH, Estradiol, inhibin B, AMH, ovarian reserve.	—

Secondary

Measure	Time frame
1. Questionnaire part: Co-morbidities, menstrual history, family history of subfertility; 2. Clinical part: Ovarian volume, uterus flow, uterus length.	—

Contacts

Public ContactM.H. Berg, van den

P.O. box 7057

mh.vandenberg@vumc.nl+31 (0)20 4446021

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)