inappropriate long term anitedepressant use cost effectiveness collaborative care depression doelmatigheid antidepressiva kosten effectiviteit depressie
Conditions
Interventions
Trial 1:
The active intervention in trial 1 (absence of indication for antidepressant drugs) implies the discontinuation of antidepressant use, following the recommendations in the Dutch multidiscipl
Sponsors
None
Eligibility
Inclusion criteria
Inclusion criteria: Long-term use of antidepressants is defined as receiving antidepressant prescriptions for at least nine months with a prescribed amount sufficient for at least 180 days of consumption in accordance with the recommended dosage.
Exclusion criteria
Exclusion criteria: 1. Current treatment in a psychiatric setting; 2. History of psychosis, bipolar disorder, or obsessive compulsive disorder; 3. Addiction; 4. Recurrent depression with 3 or more episodes; 5. Recurrent disorders with at least two relapses after antidepressant-discontinuation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Trial 1: Proportion of participants who successfully discontinue their long-term antidepressants drug use, defined as having no antidepressant drug use within the last 6 months of the follow-up and the absence of a mood- or anxiety disorder during one-year follow-up. Trial 2: Proportion of participants in which the mood or anxiety found at baseline, has remitted at one-year follow-up. | — |
Secondary
| Measure | Time frame |
|---|---|
| Assessment of dimensional measures of psychopathology with both general and disease-specific questionnaires (see listing of questionnaires in the description of the study procedure). Also, to assess the prevalence of the discontinuation syndrome we will use the Discontinuation-Emergent Signs and Symptoms (DESS) Scale [35]. The EuroQol will be included to enable the economic analyses. Costs will be measured by the Trimbos/iMTA questionnaire for Costs associated with Psychiatric Illness (TiC-P). | — |
Contacts
Public ContactE.M.H. Muskens
Postbus 9101
Outcome results
None listed