Ischemic stroke
Conditions
Interventions
Patients will receive CPAP within 24 hours after hospital admission, but at least 3 hours after alteplase infusion, during sleep and during the period of admission to the hospital.
Sponsors
ZonMW, Mediq
Eligibility
Inclusion criteria
Inclusion criteria: patiënt had first ever ischemic stroke > 18 years old onset < 4.5hours anterior circulation
Exclusion criteria
Exclusion criteria: history of stroke history of obstructive sleep apnea hemorrhagic stroke TIA
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary endpoint is feasibility defined as CPAP compliance during the study period. Compliance is expressed as the average use of CPAP per night measured by a memory card integrated in the CPAP device. Good compliance will be defined as an average usage of more than 4 hours per night. | — |
Secondary
| Measure | Time frame |
|---|---|
| - Inclusion rate - Adverse events (AE): CPAP related AEs as mentioned in section 3.5 - Percentage of withdrawal from CPAP treatment - Self-evaluation of CPAP by patients and their caregivers - Functional status: The National Institutes of Health Stroke Scale (NIHSS), modified Rankin Scale (mRS) - Cognitive status: Montreal Cognitive Assessment (MoCA), Trail Making Test (TMT) - OSA prevalence measured by polysomnography (PSG) - Epworth Sleepiness Scale (ESS) | — |
Contacts
Public ContactMyrthe Willems
OLVG
Outcome results
None listed